me too, I thnk it would. I put one in an 03 with the amp (they called it moon&tunes then) and also in an 05 with just the 4 speakers, both worked fine, no troubles. Plug and play. You can ping on dmichaelson to find out if his install in a 2006 went ok (
http://forums.genvibe.com/zerothread?id=21124 )I caught a lot of grief here for wanting such old technology as a cassette player when I did mine. Now that more people also want one, I feel vindicated